Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium

The retinal pigment epithelium (RPE) is a pigmented monolayer of cells lying between the photoreceptors and a layer of fenestrated capillaries, the choriocapillaris. Choroideremia (CHM) is an X-linked progressive degeneration of these three layers caused by the loss of function of Rab Escort protein...

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Bibliographic Details
Main Author: Wavre-Shapton, Silène T (author)
Other Authors: Tolmachova, Tanya (author), da Silva, Mafalda Lopes (author), Futter, Clare E (author), Seabra, Miguel C (author)
Format: article
Language:eng
Published: 2017
Subjects:
MACULAR DEGENERATION
RAB GTPASES
MODELS
RPE
PHAGOSOMES
PROTEOME
DISEASE
CELLS
Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Online Access:https://doi.org/10.1371/journal.pone.0057769
Country:Portugal
Oai:oai:run.unl.pt:10362/22460

Internet

https://doi.org/10.1371/journal.pone.0057769

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