Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly

The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle microtubule capture and to control spindle checkpoint signaling. In this study, we describe the molecular mechanism used by the Rod-Zw10-Zwilch complex and the adaptor Spindly to...

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Bibliographic Details
Main Author: Gama, JB (author)
Other Authors: Pereira, C (author), Simões, PA (author), Celestino, R (author), Reis, RM (author), Barbosa, DJ (author), Pires, HR (author), Carvalho, C (author), Amorim, J (author), Carvalho, AX (author), Cheerambathur, DK (author), Gassmann, R (author)
Format: article
Language:eng
Published: 2017
Subjects:
Animals
Caenorhabditis elegans/metabolism
Caenorhabditis elegans/physiology
Carrier Proteins/metabolism
Cell Cycle Proteins/metabolism
Cell Line, Tumor
Chromosomal Proteins Non-Histone/metabolism
Chromosome Segregation/physiology
Dynactin Complex/metabolism
Dyneins/metabolism
HeLa Cells
Humans
Kinetochores/metabolism
Kinetochores/physiology
Microtubule-Associated Proteins/metabolism
Microtubules/metabolism
Microtubules/physiology
Mitosis/physiology
Spindle Apparatus/metabolism
Spindle Apparatus/physiology
Online Access:http://hdl.handle.net/10216/110360
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110360

Internet

http://hdl.handle.net/10216/110360

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