Lack of TRMT2A, a tRNA methyltransferase, leads to m5U54 tRNA hypomodification and generation of tRNA-derived small RNAs

Transfer RNAs (tRNAs) are subjected to a wide variety of post-transcriptional modifications to ensure their structural stability, correct folding, and efficient protein decoding. More specifically, modifications in the D- and T-loops of tRNAs are essential for tRNA stability. However, the biological...

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Bibliographic Details
Main Author: Pereira, Marisa (author)
Other Authors: Ribeiro, Diana R. (author), Pinheiro, Miguel M. (author), Ferreira, Margarida (author), Kellner, Stefanie (author), Soares, Ana R. (author)
Format: conferenceObject
Language:eng
Published: 2021
Subjects:
tRNA
Non-coding RNAs
Transcriptomics
Epitranscriptome
Online Access:http://hdl.handle.net/10773/31485
Country:Portugal
Oai:oai:ria.ua.pt:10773/31485

Internet

http://hdl.handle.net/10773/31485

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