Towards a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

The present work aimed at designing a lipid-based nanocarrier for siRNA delivery towards two cell sub-populations within breast tumors, the cancer and the endothelial cells from angiogenic tumor blood vessels. To achieve such goal, the F3 peptide, which is specifically internalized by nucleolin over...

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Bibliographic Details
Main Author: Gomes-da-Silva, Lígia C. (author)
Other Authors: Santos, Adriana O. (author), Bimbo, Luís M. (author), Moura, Vera (author), Ramalho, José S. (author), Lima, Maria C. Pedroso de (author), Simões, Sérgio (author), Moreira, João N. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Dual-targeted delivery
Ligand-mediated targeting
SNALP
siRNA
Breast cancer
Online Access:http://hdl.handle.net/10316/21117
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/21117

Internet

http://hdl.handle.net/10316/21117

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