| Resumo: | Objective: Uterine cancer is the most common gynecologic malignant neoplasm in developed countries. While depression can increase cancer mortality, extend hospitalization and reduce the quality of life, the overlap between these conditions is understudied. This study aimed to determine depression's frequency among hospitalizations for Endometrial Cancer (EC), its association with EC's therapeutics and impact on hospitalization outcomes. Methods: A retrospective observational study was conducted using administrative data from all hospitalizations (>24 hours) that occurred in Portuguese mainland public hospitals (2008-2015). Women episodes (≥18 years) with a primary diagnosis of EC (ICD-9-CM 182.x) were selected. EC-directed procedures were analyzed through codes 68.4x, 65.6x, 40.3x, 40.5x, 68.6x, 68.9x, 68.8x, 92.20x, 92.28x and V58.11. Codes 296.2x, 296.3x and 311x were used to identify depression, and its association with length-of-stay, in-hospital mortality and readmissions was explored. Univariate and multivariate analyses were performed. Results: From 10227 hospitalizations with a primary diagnosis of EC, 533 had registered depression (5.2%). Annual depression frequency rose from 2.0% (2008) to 8.3% (2015) (p<0.01). Women coded for depression were, on average, younger (p<0.01). Surgical patients were more likely to have a registered depression code (OR=1.73, 95%IC [1.42-2.10]). No statistical differences were found for mean length-of-stay (p=0.097) and readmissions (p=0.590). In-hospital mortality was lower in patients with a depression code (aOR=0.60, 95%IC [0.37-0.99]). Conclusions: Within EC hospitalizations, depression was associated with younger age and surgery. These results identify specific characteristics of women at a greater risk for depression, who should be closely monitored, enabling timely preventive and therapeutic strategies.
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