Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs

A high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large popul...

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Bibliographic Details
Main Author: Cavadas, B (author)
Other Authors: Soares, P (author), Camacho, R (author), Brandão, A (author), Costa, M (author), Fernandes, V (author), Pereira, J (author), Rito, T (author), Samuels, DC (author), Pereira, L (author)
Format: article
Language:eng
Published: 2015
Subjects:
mtDNA; Worldwide phylogenetic tree; Mother–child pairs; Massive parallel sequencing; Heteroplasmy
Online Access:http://hdl.handle.net/10216/109576
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109576

Internet

http://hdl.handle.net/10216/109576

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