Mechanisms of the Deleterious Effects of Tamoxifen on Mitochondrial Respiration Rate and Phosphorylation Efficiency

Tamoxifen (TAM), the widely prescribed drug in the prevention and therapy of breast cancer, is a well-known modulator of estrogen receptor (ER) that also inhibits the proliferation of different cell types that lack the ER. However, the ER-independent action mechanisms of TAM and its side effects hav...

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Bibliographic Details
Main Author: Cardoso, Carla M. P. (author)
Other Authors: Custódio, José B. A. (author), Almeida, Leonor M. (author), Moreno, António J. M. (author)
Format: article
Language:eng
Published: 2001
Subjects:
tamoxifen; anticancer drug; mitochondria; respiration rate; mitochondrial transmembrane potential; mitochondrial proton leak; membrane disruption
Online Access:http://hdl.handle.net/10316/5797
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5797

Internet

http://hdl.handle.net/10316/5797

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