β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of...

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Bibliographic Details
Main Author: Branco, Ana F. (author)
Other Authors: Moreira, Ana C. (author), Cunha-Oliveira, Teresa (author), Couto, Renata (author), Sardão, Vilma A. (author), Rizvanov, Albert A. (author), Palotas, Andras (author), Oliveira, Paulo J. (author)
Format: article
Language:eng
Published: 2014
Subjects:
Animals
Calcium
Catecholamines
Humans
Mitochondria
Myocytes, Cardiac
Reactive Oxygen Species
Receptors, Adrenergic, beta
Signal Transduction
Apoptosis
Online Access:http://hdl.handle.net/10316/44868
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/44868

Internet

http://hdl.handle.net/10316/44868

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