How two become one: HJURP dimerization drives CENP-A assembly

CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nu...

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Bibliographic Details
Main Author: Bodor, Dani L (author)
Other Authors: Jansen, Lars E T (author)
Format: article
Language:eng
Published: 2016
Subjects:
Autoantigens
Centromere
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Humans
Nucleosomes
Protein Multimerization
Online Access:http://hdl.handle.net/10400.7/618
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/618

Internet

http://hdl.handle.net/10400.7/618

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