Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE...

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Bibliographic Details
Main Author: Silva, João Carlos (author)
Other Authors: Ponte, Ana (author), Mota, Margarida (author), Pinho, Rolando (author), Vieira, Nuno (author), Oliveira, Rosa (author), Mota-Carvalho, Nelson (author), Gomes, Ana Catarina (author), Afecto, Edgar (author), Carvalho, João (author)
Format: article
Language:eng
Published: 2021
Subjects:
Fecal microbiota transplantation
Carbapenamase-producing enterobacteriaceae
Multidrug-resistant infections
Decolonization
Intestinal carriage
Online Access:http://hdl.handle.net/10400.14/31815
Country:Portugal
Oai:oai:repositorio.ucp.pt:10400.14/31815
Description
Summary:Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.

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