Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells

The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive...

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Bibliographic Details
Main Author: Valente, C (author)
Other Authors: Ferreira, MJU (author), Abreu, PM (author), Gyemant, N (author), Ugocsai, K (author), Hohmann, J (author), Molnar, J (author)
Format: article
Language:eng
Published: 2015
Subjects:
Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Online Access:http://hdl.handle.net/10451/21429
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21429
Description
Summary:The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3beta9alpha,-diacetoxy-7beta-benzoyloxy-15beta-hydroxy-14-oxo-2betaH-jatropha-5E,12E-diene by spectroscopic methods, including H-1-H-1 COSY, HMQC, HMBC and NOESY.

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