Novel bioactive parathyroid hormone and related peptides in teleost fish

We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experi...

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Bibliographic Details
Main Author: Canario, Adelino V. M. (author)
Other Authors: Rotllant, J. (author), Fuentes, J. (author), Guerreiro, P. M. (author), Teodósio, H. R. (author), Power, Deborah (author), Clark, M. S. (author)
Format: article
Language:eng
Published: 2014
Subjects:
Parathyroid hormone
Parathyroid hormone-related peptide
Calciotropic
Receptor
Adenylate cyclase
Phospholipase C
Online Access:http://hdl.handle.net/10400.1/3850
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/3850
Description
Summary:We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.

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