FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

The mitochondrial toxin 3-nitropropionic acid (3-NP) has been largely used to study neurodegenerative disorders in which bioenergetic defects are implicated. In the present study, we analyzed the molecular pathways involved in FK506 neuroprotection against cell death induced by 3-NP, using cultured...

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Bibliographic Details
Main Author: Almeida, Sandra (author)
Other Authors: Domingues, António (author), Rodrigues, Luís (author), Oliveira, Catarina R. (author), Rego, A. Cristina (author)
Format: article
Language:eng
Published: 2004
Subjects:
3-Nitropropionic acid
Mitochondria
Apoptosis
Cortical neurons
Online Access:http://hdl.handle.net/10316/4776
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/4776

Internet

http://hdl.handle.net/10316/4776

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