Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against...

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Bibliographic Details
Main Author: Bacalhau, S (author)
Other Authors: Freitas, C (author), Valente, R (author), Barata, D (author), Neves, C (author), Schäfer, K (author), Lubatschofski, A (author), Schulz, A (author), Farela Neves, J (author)
Format: article
Language:eng
Published: 2013
Subjects:
BCG
Recém-Nascido
Imunodeficiência Combinada Severa
HDE UCI PED
HDE INF PED
Online Access:http://hdl.handle.net/10400.17/1566
Country:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/1566
Description
Summary:In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.

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