Sequence analysis of 5' regulatory regions of the Machado-Joseph Disease gene (ATXN3)

Machado–Joseph disease (MJD) is a late-onset autosomal dominant neurodegenerative disorder, which is caused by a coding (CAG)n expansion in the ATXN3 gene (14q32.1). The number of CAG repeats in the expanded alleles accounts only for 50 to 75 % of onset variance, the remaining variation being depend...

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Bibliographic Details
Main Author: Bettencourt, C. (author)
Other Authors: Raposo, Mafalda (author), Kazachkova, Nadiya (author), Santos, Cristina (author), Kay, Teresa (author), Vasconcelos, João (author), Maciel, P. (author), Donis, Karina (author), Pereira, Maria Luiza Saraiva (author), Jardim, Laura (author), Sequeiros, Jorge (author), Armas, Jácome Bruges (author), Lima, M. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Ataxin-3
5′ regulatory regions
5′ UTR
MJD
Promoter
SCA3
Science & Technology
Online Access:http://hdl.handle.net/1822/20476
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/20476

Internet

http://hdl.handle.net/1822/20476

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