Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, ind...

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Detalhes bibliográficos
Autor principal: Vinagre, Tânia (author)
Outros Autores: Moncaut, Natalia (author), Carapuço, Marta (author), Nóvoa, Ana (author), Bom, Joana (author), Mallo, Moisés (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Animals
Bone Development
Fibroblast Growth Factors
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Biological
Models, Genetic
Muscle Development
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Phenotype
Platelet-Derived Growth Factor
Gene Expression Regulation, Developmental
Texto completo:http://hdl.handle.net/10400.7/669
País:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/669

Texto Completo

http://hdl.handle.net/10400.7/669

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