Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results...

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Bibliographic Details
Main Author: Coimbra, Patrícia Manuela Almeida (author)
Other Authors: Ferreira, Paula Cristina Nunes (author), Sousa, Herminio de (author), Batista, Patrícia Sofia Pinhanços (author), Rodrigues, Miguel (author), Correia, Ilídio Joaquim Sobreira (author), Gil, Helena (author)
Format: article
Language:eng
Published: 2018
Subjects:
Polymeric scaffold
Polyelectrolyte complexes
Cytotoxicity
Osteoblasts
Online Access:http://hdl.handle.net/10400.6/4627
Country:Portugal
Oai:oai:ubibliorum.ubi.pt:10400.6/4627
Description
Summary:In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

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