Evaluating the forensic informativeness of mtDNA haplogroup H sub-typing on a Eurasian scale

The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typin...

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Bibliographic Details
Main Author: Pereira, L (author)
Other Authors: Richards, M (author), Goios, A (author), Alonso, A (author), Albarrán, C (author), Garcia, O (author), Behar, DM (author), Gölge, M (author), Hatina, J (author), Al-Gazali, L (author), Bradley, DG (author), Macaulay, V (author), Amorim, A (author)
Format: article
Language:eng
Published: 2006
Subjects:
Human mtDNA
Haplogroup H
Haplotype diversity
HVRI and HVRII
Coding-region SNPs
Eurasia
Online Access:http://hdl.handle.net/10216/109577
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109577
Description
Summary:The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power is low in some Eurasian populations. We show that a small set (eight) of coding-region SNPs resolves a substantial proportion of the identical haplotypes, as defined by control-region variation alone. Moreover, this SNP set, while substantially increasing the discriminating efficiency in most Eurasian populations by roughly equal amounts, discloses population-specific profiles.

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