Synthesis of new tacrine analogues from 4-amino-1H-pyrrole-3-carbonitrile

An easy preparation of 4-aminopyrrole-3-carbonitrile derivatives, and their transformation into new substituted pyrrolo[3,2-b]pyridines is described, in one step, via Friedländer reaction under microwave irradiation and classical heating methods. The use of microwave irradiation led to high conversi...

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Bibliographic Details
Main Author: Salaheldin, Abdellatif M. (author)
Other Authors: Campos, Ana M. F. Oliveira (author), Parpot, Pier (author), Rodrigues, Lígia M. (author), Oliveira, M. Manuel (author), Peixoto, Francisco (author)
Format: article
Language:eng
Published: 2010
Subjects:
Tacrine
Friedländer reaction
Alzheimer disease
Acetylcholinesterase
Thorpe-Ziegler cyclization
Microwave irradiation
Science & Technology
Online Access:http://hdl.handle.net/1822/10646
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/10646
Description
Summary:An easy preparation of 4-aminopyrrole-3-carbonitrile derivatives, and their transformation into new substituted pyrrolo[3,2-b]pyridines is described, in one step, via Friedländer reaction under microwave irradiation and classical heating methods. The use of microwave irradiation led to high conversion and shorter times.

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