Amino acids as selective acylating agents: regioselective N-1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine
The acylation of bioactive primaquine-based imidazolidin-4-ones was studied using N-chi-Boc-protected glycine as acylating agent. Two synthesis routes, eight different coupling methods and seven distinct solvents were compared. Mild carbodiimide-based couplings on high dielectric constant solvents s...
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Format: | article |
| Language: | eng |
| Published: |
2008
|
| Subjects: | |
| Online Access: | https://repositorio-aberto.up.pt/handle/10216/82026 |
| Country: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/82026 |