A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the recessive genetic disease cystic fibrosis, where the chloride transport across the apical membrane of epithelial cells mediated by the CFTR protein is impaired. CFTR protein trafficking to the plasma membrane...

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Bibliographic Details
Main Author: Loureiro, Cláudia Almeida (author)
Other Authors: Pinto, Francisco R. (author), Barros, Patrícia (author), Matos, Paulo (author), Jordan, Peter (author)
Format: article
Language:eng
Published: 2021
Subjects:
Cell Membrane
Chlorides
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial Cells
Lung
Phosphopeptides
Phosphorylation
Phosphotyrosine
Protein Domains
Protein Interaction Maps
Protein Kinase Inhibitors
Src Homology 2 Domain-Containing, Transforming Protein 1
Syk Kinase
Signal Transduction
Vias de Transdução de Sinal e Patologias Associadas
Online Access:http://hdl.handle.net/10400.18/7343
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7343

Internet

http://hdl.handle.net/10400.18/7343

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