Dependence of cell proliferation on the morphology of starch based scaffolds for tissue engineering

[Excerpt] In tissue engineering (TE), several biological, mechanical and geometrical design constraints need to be addressed in order to create an adequate micro-environment for cells response. In this study, the correlation between architectural features of the scaffold construct and cellular behav...

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Bibliographic Details
Main Author: Chung, S. (author)
Other Authors: Martins, A. (author), Correlo, V. M. (author), Oliveira, J. T. (author), Marques, A. P. (author), Neves, N. M. (author), Mano, J. F. (author), Sousa, R. A. (author), Reis, R. L. (author)
Format: conferenceObject
Language:eng
Published: 2008
Subjects:
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
Online Access:http://hdl.handle.net/1822/59209
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/59209
Description
Summary:[Excerpt] In tissue engineering (TE), several biological, mechanical and geometrical design constraints need to be addressed in order to create an adequate micro-environment for cells response. In this study, the correlation between architectural features of the scaffold construct and cellular behavior was investigated for a blend of starch and polycaprolactone (SPCL). The aim was to determine the effects of scaffold parameters on mechanical properties on cell seeding efficiency and proliferation of human osteoblast-like cells (SaOs-2) of scaffolds obtained via Rapid Prototyping (Bioplotter) and fiber bonding. For fiber bonding, a L8 design of experiment approach was used to produce different scaffold morphologies and properties by systematically varying processing parameters. [...]

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