Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells

Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested...

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Bibliographic Details
Main Author: Xavier, Cristina P. R. (author)
Other Authors: Lima, Cristóvão F. (author), Pedro, Dalila Fernanda Neto (author), Wilson, Jonathan M. (author), Kristiansen, K. (author), Wilson, Cristina Pereira (author)
Format: article
Language:eng
Published: 2013
Subjects:
Ursolic acid
Colorectal carcinoma
Cell death
Autophagy
JNK
5-fluorouracil
Science & Technology
Online Access:https://hdl.handle.net/1822/23533
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/23533

Internet

https://hdl.handle.net/1822/23533

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