Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins)...

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Detalhes bibliográficos
Autor principal: Oliveira, Ana M. A. G. (author)
Outros Autores: Campos, Ana M. F. Oliveira (author), Raposo, M. Manuela M. (author), Machado, António E. H. (author), Puapairoj, Prapawadee (author), Pedro, Madalena (author), Nascimento, Maria São José (author), Portela, César (author), Afonso, Carlos A. M. (author), Pinto, Madalena (author)
Formato: article
Idioma:eng
Publicado em: 2006
Assuntos:
Furocoumarins
Benzopsoralens
Antitumor
Computational studies
Science & Technology
Texto completo:http://hdl.handle.net/1822/5168
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/5168
Descrição
Resumo:Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.

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