Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins)...

Full description

Bibliographic Details
Main Author: Oliveira, Ana M. A. G. (author)
Other Authors: Campos, Ana M. F. Oliveira (author), Raposo, M. Manuela M. (author), Machado, António E. H. (author), Puapairoj, Prapawadee (author), Pedro, Madalena (author), Nascimento, Maria São José (author), Portela, César (author), Afonso, Carlos A. M. (author), Pinto, Madalena (author)
Format: article
Language:eng
Published: 2006
Subjects:
Furocoumarins
Benzopsoralens
Antitumor
Computational studies
Science & Technology
Online Access:http://hdl.handle.net/1822/5168
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/5168
Description
Summary:Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.

Similar Items