Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytes

Transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis is associated with activation of E2F transcription factors and p53 stabilization through Mdm-2, thus potentially modulating a number of target genes. In previous studies, we have sh

Bibliographic Details
Main Author: Sola, S (author)
Other Authors: Ma, XM (author), Castro, RE (author), Kren, BT (author), Steer, CJ (author), Rodrigues, CMP (author)
Format: article
Language:eng
Published: 2015
Subjects:
Biochemistry & Molecular Biology
Online Access:http://hdl.handle.net/10451/21065
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21065
Description
Summary:Transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis is associated with activation of E2F transcription factors and p53 stabilization through Mdm-2, thus potentially modulating a number of target genes. In previous studies, we have sh

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