Functional and conformational changes in the aspartic protease cardosin A induced by TFE

Conformational and functional changes of cardosin A, an aspartic protease of vegetal origin, in the presence of 2,2,2-trifluoroethanol (TFE), were assessed. TFE induced alterations of cardosin activity and conformation that differed with the solvent concentration. MD simulations showed that there ar...

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Detalhes bibliográficos
Autor principal: Fraga, Ana Sofia (author)
Outros Autores: Esteves, Ana Cristina (author), Micaelo, Nuno (author), Cruz, Pedro F. (author), Brito, Rui M. M. (author), Nutley, Margaret (author), Cooper, Alan (author), Barros, Marlene M. T. (author), Pires, Euclides M. V. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Aspartic proteases
Trifluoroethanol
Circular dichroism
Calorimetry
Molecular dynamics simulations
Texto completo:http://hdl.handle.net/10773/26797
País:Portugal
Oai:oai:ria.ua.pt:10773/26797

Texto Completo

http://hdl.handle.net/10773/26797

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