Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study

Introduction:We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progran...

ver descrição completa

Detalhes bibliográficos
Autor principal: Poos, Jackie M (author)
Outros Autores: Russell, Lucy L (author), Peakman, Georgia (author), Bocchetta, Martina (author), Greaves, Caroline V (author), Jiskoot, Lize C (author), van der Ende, Emma L (author), Seelaar, Harro (author), Papma, Janne M (author), van den Berg, Esther (author), Pijnenburg, Yolande A L (author), Borroni, Barbara (author), Sánchez-Valle, Raquel (author), Moreno, Fermin (author), Laforce, Robert (author), Graff, Caroline (author), Synofzik, Matthias (author), Galimberti, Daniela (author), Rowe, James B (author), Masellis, Mario (author), Tartaglia, Carmela (author), Finger, Elizabeth (author), Vandenberghe, Rik (author), de Medonça, Alexandre (author), Tagliavini, Fabrizio (author), Butler, Chris R (author), Santana, Isabel (author), Ber, Isabelle Le (author), Gerhard, Alex (author), Ducharme, Simon (author), Levin, Johannes (author), Danek, Adrian (author), Otto, Markus (author), Sorbi, Sandro (author), Pasquier, Florence (author), van Swieten, John C (author), Rohrer, Jonathan D. (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
cognition
episodic memory
executive function
frontal lobe
frontotemporal dementia
genetic disorders
neuropsychology
temporal lobe
voxel-basedmorphometry
Texto completo:http://hdl.handle.net/10316/103558
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103558
Descrição
Resumo:Introduction:We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73microtubule-associated protein tau [MAPT]) and 290 controls.Group differences and correlations with other neuropsychological tests were examined.We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task,while no deficits were found in presymptomaticGRNmutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlatedwith graymatter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPTassociated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.

Registros relacionados