The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Targeting multiple cellular populations is of high therapeutic relevance for the tackling of solid tumors heterogeneity. Herein, the ability of pegylated and pH-sensitive liposomes, functionalized with the nucleolin-binding F3 peptide and containing doxorubicin (DXR)/C6-ceramide synergistic combinat...

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Bibliographic Details
Main Author: Cruz, Ana F. (author)
Other Authors: Caleiras, Mariana B. (author), Fonseca, Nuno A. (author), Gonçalves, Nélio (author), Mendes, Vera M. (author), Sampaio, Susana F. (author), Moura, Vera (author), Melo, Joana B. (author), Almeida, Ramiro D. (author), Manadas, Bruno (author), Simões, Sérgio Paulo (author), Moreira, João N. (author)
Format: article
Language:eng
Published: 2021
Subjects:
nucleolin
ovarian cancer
doxorubicin
C6-ceramide
synergistic combination
phospho-Akt downregulation
Online Access:http://hdl.handle.net/10316/103812
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103812

Internet

http://hdl.handle.net/10316/103812

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