Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in...

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Bibliographic Details
Main Author: Martin, C. (author)
Other Authors: Murray, J. (author), Carroll, P. (author), Leitch, A. (author), Mackenzie, K. (author), Halachev, M. (author), Fetit, A. (author), Keith, C. (author), Bicknell, L. (author), Fluteau, A. (author), Gautier, P. (author), Hall, E. (author), Joss, S. (author), Soares, G. (author), Silva, J. (author), Bober, M. (author), Duker, A. (author), Wise, C. (author), Quigley, A. (author), Phadke, S. (author), Wood, A. (author), Vagnarelli, P. (author), Jackson, A. (author)
Format: article
Language:eng
Published: 2017
Subjects:
condensin
microcephaly
neurodevelopment
decatenation
Online Access:http://hdl.handle.net/10400.16/2129
Country:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2129

Internet

http://hdl.handle.net/10400.16/2129

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