Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in...

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Detalhes bibliográficos
Autor principal: Martin, C. (author)
Outros Autores: Murray, J. (author), Carroll, P. (author), Leitch, A. (author), Mackenzie, K. (author), Halachev, M. (author), Fetit, A. (author), Keith, C. (author), Bicknell, L. (author), Fluteau, A. (author), Gautier, P. (author), Hall, E. (author), Joss, S. (author), Soares, G. (author), Silva, J. (author), Bober, M. (author), Duker, A. (author), Wise, C. (author), Quigley, A. (author), Phadke, S. (author), Wood, A. (author), Vagnarelli, P. (author), Jackson, A. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
condensin
microcephaly
neurodevelopment
decatenation
Texto completo:http://hdl.handle.net/10400.16/2129
País:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2129

Texto Completo

http://hdl.handle.net/10400.16/2129

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