Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were evaluated for their stability at pH 74 in buffer and in human plasma, affinity toward hPEPT1, cytotoxicity, and antiretroviral activity. The dipept...

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Bibliographic Details
Main Author: Cledir Santos (author)
Other Authors: Jose Morais (author), Luis Gouveia (author), Erik de Clercq (author), Christophe Pannecouque (author), Carsten Uhd Nielsen (author), Bente Steffansen (author), Rui Moreira (author), Paula Gomes (author)
Format: article
Language:eng
Published: 2008
Subjects:
Medicina básica
Basic medicine
Online Access:https://hdl.handle.net/10216/82105
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/82105

Internet

https://hdl.handle.net/10216/82105

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