Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis

The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxa...

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Detalhes bibliográficos
Autor principal: Lima, R. (author)
Outros Autores: Fernandes, Carla S. (author), Dias, Ricardo P. (author), Ishikawa, Takuji (author), Imai, Yohsuke (author), Yamaguchi, Takami (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2014
Assuntos:
Blood flow
Bifurcation
Microchannel
Microvascular networks
Texto completo:http://hdl.handle.net/10198/10314
País:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/10314
Descrição
Resumo:The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.

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