Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neutralize HIV-1 infectivity

We recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a

Detalhes bibliográficos
Autor principal: da Silva, FA (author)
Outros Autores: Santa-Marta, M (author), Freitas-Vieira, A (author), Mascarenhas, P (author), Barahona, I (author), Moniz-Pereira, J (author), Gabuzda, D (author), Goncalves, J (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemistry & Molecular Biology
Texto completo:http://hdl.handle.net/10451/21600
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21600
Descrição
Resumo:We recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a

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