Fine tuning neuronal targeting of nanoparticles by adjusting the ligand grafting density and combining PEG spacers of different length

Poly(ethylene glycol) (PEG) has been extensively used to coat the surface of nanocarriers to improve their physicochemical properties and allow the grafting of targeting moieties. Still, to date there is no common agreement on the ideal PEG coverage-density or length to be used for optimum vector pe...

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Bibliographic Details
Main Author: Gomes, CP (author)
Other Authors: Leiro, V (author), Lopes, CD (author), Spencer, AP (author), Pêgo, AP (author)
Format: article
Language:eng
Published: 2018
Subjects:
Cellular uptake
Nanoparticle surface modification/functionalization
PEGylation
Spacer length
Targeted nanoparticles
Online Access:https://hdl.handle.net/10216/121133
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/121133

Internet

https://hdl.handle.net/10216/121133

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