Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli.

A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF...

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Bibliographic Details
Main Author: Manageiro, V (author)
Other Authors: Félix, D (author), Jones-Dias, D (author), Sampaio, D (author), Vieira, L (author), Sancho, L (author), Ferreira, E (author), Caniça, M (author)
Format: article
Language:eng
Published: 2018
Subjects:
Escherichia coli
QepA4 gene variant
Online Access:http://hdl.handle.net/10400.10/1996
Country:Portugal
Oai:oai:repositorio.hff.min-saude.pt:10400.10/1996
Description
Summary:A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.

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