Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci

Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resu...

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Detalhes bibliográficos
Autor principal: Barros, Patrícia (author)
Outros Autores: Amaral, Andreia (author), Abrantes, Leonor (author), Oliveira, Tiago (author), Louro, Henriqueta (author), Silva, Maria João (author), Jordan, Peter (author), Gama-Carvalho, Margarida (author), Matos, Paulo (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2018
Assuntos:
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
RAC1
Reparação do DNA
Texto completo:http://hdl.handle.net/10400.18/5193
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5193
Descrição
Resumo:Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.

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