Analysis of extracellular metabolome by HS-SPME/GC–MS: optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity

Two methods based on headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography-mass spectrometry (GC-MS) were developed to study in vitro the volatile exometabolome, which were then further tested in a pilot study to evaluate galactosamine-induced hepatotoxicity. The analysis of...

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Bibliographic Details
Main Author: Araújo, Ana Margarida (author)
Other Authors: Moreira, Nathalie (author), Lima, Ana Rita (author), Bastos, Maria de Lourdes (author), Carvalho, Félix (author), Carvalho, Márcia (author), Guedes de Pinho, Paula (author)
Format: article
Language:eng
Published: 2021
Subjects:
Headspace solid-phase microextraction
Gas chromatography–mass spectrometry
Central composite design
Exometabolome
Primary mouse hepatocytes
Galactosamine
Online Access:http://hdl.handle.net/10284/10014
Country:Portugal
Oai:oai:bdigital.ufp.pt:10284/10014

Internet

http://hdl.handle.net/10284/10014

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