IL10 Low-Frequency Variants in Behçet's Disease Patients

To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's dise...

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Bibliographic Details
Main Author: Matos, M (author)
Other Authors: Xavier, JM (author), Abrantes, P (author), Sousa, I (author), Rei, N (author), Davatchi, F (author), Shahram, F (author), Jesus, G (author), Barcelos, F (author), Vedes, J (author), Salgado, Manuel (author), Abdollahi, B (author), Nadji, A (author), Moraes-Fontes, MF (author), Shafiee, N (author), Ghaderibarmi, F (author), Vaz Patto, J (author), Crespo, J (author), Oliveira, SA (author)
Format: article
Language:eng
Published: 2016
Subjects:
Behçet's disease
IL10
Low-frequency variants
HCC DAUTOIM
Online Access:http://hdl.handle.net/10400.17/2548
Country:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/2548
Description
Summary:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility.

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