IL10 Low-Frequency Variants in Behçet's Disease Patients

To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's dise...

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Detalhes bibliográficos
Autor principal: Matos, M (author)
Outros Autores: Xavier, JM (author), Abrantes, P (author), Sousa, I (author), Rei, N (author), Davatchi, F (author), Shahram, F (author), Jesus, G (author), Barcelos, F (author), Vedes, J (author), Salgado, Manuel (author), Abdollahi, B (author), Nadji, A (author), Moraes-Fontes, MF (author), Shafiee, N (author), Ghaderibarmi, F (author), Vaz Patto, J (author), Crespo, J (author), Oliveira, SA (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Behçet's disease
IL10
Low-frequency variants
HCC DAUTOIM
Texto completo:http://hdl.handle.net/10400.17/2548
País:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/2548
Descrição
Resumo:To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility.

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