Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in...

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Detalhes bibliográficos
Autor principal: Singh, Rajesh K (author)
Outros Autores: Liao, Wenjia (author), Tracey-White,  Dhani (author), Recchi, Chiara (author), Tolmachova, Tanya (author), Rankin, Sara M (author), Hume, Alistair N (author), Seabra, Miguel C (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Neutrophil
EFFECTORS
GRANULES
ELASTASE
GRISCELLI-SYNDROME
Cell migration
Chemotaxis
RAB27A
INFLAMMATION
IMMUNITY
EXOCYTOSIS
CELLS
ACTIVATION
Uropod
Rab27a
Texto completo:http://hdl.handle.net/10362/21954
País:Portugal
Oai:oai:run.unl.pt:10362/21954

Texto Completo

http://hdl.handle.net/10362/21954

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