Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in...

Full description

Bibliographic Details
Main Author: Singh, Rajesh K (author)
Other Authors: Liao, Wenjia (author), Tracey-White,  Dhani (author), Recchi, Chiara (author), Tolmachova, Tanya (author), Rankin, Sara M (author), Hume, Alistair N (author), Seabra, Miguel C (author)
Format: article
Language:eng
Published: 2017
Subjects:
Neutrophil
EFFECTORS
GRANULES
ELASTASE
GRISCELLI-SYNDROME
Cell migration
Chemotaxis
RAB27A
INFLAMMATION
IMMUNITY
EXOCYTOSIS
CELLS
ACTIVATION
Uropod
Rab27a
Online Access:http://hdl.handle.net/10362/21954
Country:Portugal
Oai:oai:run.unl.pt:10362/21954

Internet

http://hdl.handle.net/10362/21954

Similar Items