Endothelial factors and stroke risk in pediatric sickle cell anemia patients: insights from VCAM1 and ITGA4 variants

Sickle cell anemia (SCA) arises from homozygosity for the mutation c.20A>T in the HBB gene which originates hemoglobin S (HbS). In hypoxic conditions, HbS polymerizes inside erythrocytes deforming them and ultimately leading to hemolysis and vaso-occlusion. SCA shows a multifactorial-like behavio...

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Bibliographic Details
Main Author: Silva, Marisa (author)
Other Authors: Vargas, Sofia (author), Coelho, Andreia (author), Mendonça, Joana (author), Vieira, Luís (author), Kjollerstrom, Paula (author), Maia, Raquel (author), Silva, Rute (author), Dias, Alexandra (author), Ferreira, Teresa (author), Morais, Anabela (author), Mota Soares, Isabel (author), Lavinha, João (author), Faustino, Paula (author)
Format: conferenceObject
Language:eng
Published: 2018
Subjects:
Doenças Genéticas
Doenças Raras
Drepanocitose
Anemia das Células Falciformes
AVC
Stroke
Sickle Cell Anemia
Genetic Variants
Factores Modificadores
Online Access:http://hdl.handle.net/10400.18/4929
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/4929

Internet

http://hdl.handle.net/10400.18/4929

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