Endothelial factors and stroke risk in pediatric sickle cell anemia patients: insights from VCAM1 and ITGA4 variants

Sickle cell anemia (SCA) arises from homozygosity for the mutation c.20A>T in the HBB gene which originates hemoglobin S (HbS). In hypoxic conditions, HbS polymerizes inside erythrocytes deforming them and ultimately leading to hemolysis and vaso-occlusion. SCA shows a multifactorial-like behavio...

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Detalhes bibliográficos
Autor principal: Silva, Marisa (author)
Outros Autores: Vargas, Sofia (author), Coelho, Andreia (author), Mendonça, Joana (author), Vieira, Luís (author), Kjollerstrom, Paula (author), Maia, Raquel (author), Silva, Rute (author), Dias, Alexandra (author), Ferreira, Teresa (author), Morais, Anabela (author), Mota Soares, Isabel (author), Lavinha, João (author), Faustino, Paula (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2018
Assuntos:
Doenças Genéticas
Doenças Raras
Drepanocitose
Anemia das Células Falciformes
AVC
Stroke
Sickle Cell Anemia
Genetic Variants
Factores Modificadores
Texto completo:http://hdl.handle.net/10400.18/4929
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/4929

Texto Completo

http://hdl.handle.net/10400.18/4929

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