Optimizations studies on the microwave assisted synthesis of antimicrobial Peptaibols

We present a systematic study on the best conditions to achieve the microwave-assisted solid phase peptide synthesis of a selected peptaibol, namely the pentapeptide Peptaibolin (Ac-Leu-Aib-Leu-Aib-Phol), by using several resins and different coupling and cleavage conditions aiming at a future synth...

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Bibliographic Details
Main Author: Castro, Vânia I. B. (author)
Other Authors: Carvalho, Carina Martins (author), Fernandes, Rui D. V. (author), Aguiam, Nádia (author), Costa, Susana P. G. (author), Pereira-Lima, Sílvia M. M. A. (author)
Format: conferenceObject
Language:eng
Published: 2013
Subjects:
Peptaibols
Microwave assisted synthesis
Online Access:http://hdl.handle.net/1822/37372
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/37372
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Summary:We present a systematic study on the best conditions to achieve the microwave-assisted solid phase peptide synthesis of a selected peptaibol, namely the pentapeptide Peptaibolin (Ac-Leu-Aib-Leu-Aib-Phol), by using several resins and different coupling and cleavage conditions aiming at a future synthesis of mimetics of larger members of the peptaibol family bearing bulkier unnatural α,α-dialkylglycines.

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