Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes

Successful transmission of tuberculosis depends on the interplay of human behavior, host immune responses, and Mycobacterium tuberculosis virulence factors. Previous studies have been focused on identifying host risk factors associated with increased transmission, but the contribution of specific ge...

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Detalhes bibliográficos
Autor principal: Nebenzahl-Guimaraes, Hanna (author)
Outros Autores: van Laarhoven, Arjan (author), Farhat, Maha R. (author), Koeken, Valerie A. C. M. (author), Mandemakers, Jornt J. (author), Zomer, Aldert (author), van Hijum, Sacha A. F. T. (author), Netea, Mihai G. (author), Murray, Megan (author), van Crevel, Reinout (author), van Soolingen, Dick (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Genetic Markers
Immunity, Cellular
Mycobacterium tuberculosis
Phenotype
tuberculosis
transmission
bacterial genomes
immunology
Ciências Médicas::Medicina Básica
Science & Technology
Texto completo:http://hdl.handle.net/1822/62014
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/62014
Descrição
Resumo:Successful transmission of tuberculosis depends on the interplay of human behavior, host immune responses, and Mycobacterium tuberculosis virulence factors. Previous studies have been focused on identifying host risk factors associated with increased transmission, but the contribution of specific genetic variations in mycobacterial strains themselves are still unknown.

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