Evaluation of Genotype-Based Gene Expression Model Performance: A cross-framework and cross-dataset study

Predicting gene expression from genotyped data is valuable for studying inaccessible tissues such as the brain. Herein we present eGenScore, a polygenic/poly-variation method, and compare it with PrediXcan, a method based on regularized linear regression using elastic nets. While both methods have t...

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Bibliographic Details
Main Author: Tavares, V. (author)
Other Authors: Monteiro, J. (author), Vassos, E. (author), Coleman, J. (author), Prata, D. (author)
Format: article
Language:eng
Published: 2021
Subjects:
Expression quantitative trait loci
Gene expression
Genome wide association study
Polygenic score
Transcriptome
Online Access:http://hdl.handle.net/10071/23620
Country:Portugal
Oai:oai:repositorio.iscte-iul.pt:10071/23620

Internet

http://hdl.handle.net/10071/23620

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