The mechanism through which translation-termination codons are recognized as premature

About one third of the gene mutations found in human genetic disorders, including cancer, result in premature termination codons (PTCs) and the rapid degradation of their mRNAs by nonsense-mediated decay (NMD). NMD controls the quality of eukaryotic gene expression. The strength of the NMD response...

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Bibliographic Details
Main Author: Onofre, Claudia (author)
Other Authors: Menezes, Juliane (author), Peixeiro, Isabel (author), Barbosa, Cristina (author), Romão, Luísa (author)
Format: conferenceObject
Language:eng
Published: 2017
Subjects:
Nonsense-mediated Decay (NMD)
Human Genetic Disorders
mRNA Translation
Expressão Génica
Genómica Funcional e Estrutural
Online Access:http://hdl.handle.net/10400.18/5133
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5133

Internet

http://hdl.handle.net/10400.18/5133

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