Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition and potential impact on p53

The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well...

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Detalhes bibliográficos
Autor principal: Long, Solida (author)
Outros Autores: Loureiro, Joana B. (author), Carvalho, Carla (author), Gales, Luís (author), Saraiva, Lucília (author), Pinto, Madalena M. M. (author), Puthongking, Ploenthip (author), Sousa, Emília (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Aminocarbazoles
Heptaphylline
Alkaloids
Tumor
p53
Mutant
Texto completo:http://hdl.handle.net/1822/73355
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73355

Texto Completo

http://hdl.handle.net/1822/73355

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