3D modeling of esophageal development using human PSC-Derived basal progenitors reveals a critical role for notch signaling

Pluripotent stem cells (PSCs) could provide a powerful system to model development of the human esophagus, whose distinct tissue organization compared to rodent esophagus suggests that developmental mechanisms may not be conserved between species. We therefore established an efficient protocol for g...

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Bibliographic Details
Main Author: Zhang, Yongchun (author)
Other Authors: Yang, Ying (author), Jiang, Ming (author), Huang, Sarah Xuelian (author), Zhang, Wanwei (author), Al Alam, Denise (author), Danopoulos, Soula (author), Mori, Munemasa (author), Chen, Ya-Wen (author), Balasubramanian, Revathi (author), Chuva de Sousa Lopes, Susana M. (author), Serra, Carlos (author), Bialecka, Monika (author), Kim, Eugene (author), Lin, Sijie (author), Toste de Carvalho, Ana Luisa Rodrigues (author), Riccio, Paul N. (author), Cardoso, Wellington V. (author), Zhang, Xin (author), Snoeck, Hans-Willem (author), Que, Jianwen (author)
Format: article
Language:eng
Published: 2018
Subjects:
Human embryonic stem cells
Human-induced pluripotent stem cell
Basal cells
Esophagus
Organoids
BMP
TGF-ß
WNT
NOTCH
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/58495
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/58495

Internet

http://hdl.handle.net/1822/58495

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